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While some studies using models of cortical stroke, aspiration injury, and traumatic brain injury (TBI) have reported myelination of tNs from diverse donor sources, it remains unclear how many of the tNs are myelinated and if these neurons can acquire the complex, region-specific myelination patterns characteristic of the host cortex

However, under more extreme conditions such as: 1) inadequate intake of foodstuffs containing the antioxidants, 2) excessive intake of pro-oxidants, 3) exposure to noxious chemicals or ultraviolet light, 4) injury/wounds, and/or 5) intense exercise, especially eccentric exercise, the body's endogenous antioxidant system is not able to effectively remove excessive ROS production

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J Neuroinflamm (2019) 16(1):165